OrbiMed Advisors LLC Insider Trading Activity

Institutional FilerDirector · CIK 1055951

34

Total trades

$78.7M

Total volume

May 11, 2026

Last activity

SION

Sionna Therapeutics, Inc.

OrbiMed Advisors LLC, an institutional filer, recorded 34 transactions over the last 12 months across 8 companies totaling $78.7M.

Activity concentrated in SION with 17 filings. The largest single transaction was a sale of SION for $10.5M on Apr 15, 2026.

Performance Scorecard

Forward stock performance after each transaction by OrbiMed Advisors LLC. Buy returns measure price movement after open-market purchases; sell-avoided measures the loss avoided after open-market sales. Success rate counts trades where the insider's direction was right.

PERIODAVG BUY RETURNAVG SELL AVOIDEDSUCCESS RATETRADES
30 days+312.7%-216.9%70%33
90 days+421.2%-421.0%79%19
120 days+404.7%-424.9%74%19

Performance based on stock price movement after each transaction date. Past results do not predict future returns. Not financial advice.

Price & Trades

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Recent Trades

DATETICKERTYPESHARESPRICEVALUEROLE
May 11, 2026SIONSell184,639$46.22$8.5MDirector
May 8, 2026SIONSell59,767$44.58$2.7MDirector
May 7, 2026SIONSell48,546$44.61$2.2MDirector
Apr 21, 2026PRLDBuy1,689,189$4.44$7.5MDirector
Apr 21, 2026PRLDBuy1,126,126$4.44$5.0MDirector
Apr 18, 2026SIONSell2,948$44.52$131KDirector
Apr 17, 2026SIONSell52,397$44.68$2.3MDirector
Apr 16, 2026SIONSell226,906$45.34$10.3MDirector
Apr 16, 2026TRAWBuy597,729$1.67$998K10%+ Owner
Apr 15, 2026SIONSell235,863$44.64$10.5MDirector
Apr 14, 2026SIONSell47,814$44.51$2.1MDirector
Apr 8, 2026ACETSell32,523$6.29$205K10%+ Owner
Apr 8, 2026ACETSell40,416$6.52$264K10%+ Owner
Apr 7, 2026ACETSell29,319$6.53$191K10%+ Owner
Apr 7, 2026ACETSell2,400$6.38$15K10%+ Owner
Feb 3, 2026SIONSell29,063$44.58$1.3MDirector
Feb 2, 2026SIONSell1,890$44.57$84KDirector
Dec 24, 2025SIONSell33,356$44.55$1.5MDirector
Dec 19, 2025SIONSell875$44.49$39KDirector
Dec 18, 2025SIONSell100$44.49$4KDirector
Dec 17, 2025SIONSell900$44.50$40KDirector
Nov 26, 2025SIONSell1,600$44.49$71KDirector
Nov 25, 2025SIONSell11,890$44.60$530KDirector
Nov 24, 2025SIONSell94,583$44.54$4.2MDirector
Oct 23, 2025PMVPSell1,000,000$1.52$1.5M10%+ Owner
Oct 8, 2025ACETBuy3,500,000$1.00$3.5M10%+ Owner
Oct 8, 2025ACETBuy1,500,000$1.00$1.5M10%+ Owner
Sep 10, 2025PMVPSell500,000$1.80$900K10%+ Owner
Aug 25, 2025STTKBuy5,255,106$0.87$4.6MDirector
Aug 25, 2025STTKBuy1,051,021$0.87$912KDirector
Jun 27, 2025CRVSSell1,176,332$4.16$4.9MDirector
Jun 26, 2025PASGSell213,257$0.33$70K10%+ Owner
Jun 25, 2025PASGSell138,800$0.33$46K10%+ Owner
Jun 24, 2025PASGSell231,600$0.35$81K10%+ Owner

Top Companies Traded

TICKERCOMPANYTRADESTOTAL VOLUME
SIONSionna Therapeutics, Inc.17$46.5M
ACETAdicet Bio, Inc.6$5.7M
PASGPassage BIO, Inc.3$197K
PRLDPrelude Therapeutics Inc2$12.5M
PMVPPMV Pharmaceuticals, Inc.2$2.4M
STTKShattuck Labs, Inc.2$5.5M
TRAWTraws Pharma, Inc.1$998K
CRVSCorvus Pharmaceuticals, Inc.1$4.9M

Other insiders at Sionna Therapeutics, Inc.

6 other tracked filers at SION.